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73269

INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES: V- THERMODYNAMICS OF TEMAZEPAM SOLUBILIZATION

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Last updated: 25 Dec 2024

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Abstract

Temazepam was solubilized by series of non-ionic surfactant solutions including polysorbates, Eumulgins, Brjs, Myrjs and cetomacrogol as well as ionic ones including sodium lauryl sulphate and cetrimide at different temperatures. Among the non-ionic surfactant solutions investigated, polysorbate 80 was found to be the most efficient solubilizer at different temperatures investigated, while Myrj 59 was the least. For the ionic ones, sodium lauryl sulphate proved to be more efficient than cetrimide. Thermodynamic parameters for the solubilization of temazepam in polysorbates and Eumulgins were calculated in order to investigate the thermal process of micellar solubilization. These parameters include the heat of solution, DH, the free energy change for the transfer of temazepam from aqueous phase to micellar phase. DG and the entropy of solubilization, DS. For all systems DG was a negative value indicating spontaneous solubilization. The positive values of entropy, DS, suggest a decrease in the degree of ordering when temazepam dissolved in the micellar phase. This positive values of entropy also implies that temazepam molecules into micelle interior.

DOI

10.21608/bfsa.1988.73269

Authors

First Name

B.

Last Name

Mulley

MiddleName

A.

Affiliation

School of Pharmacy, Bradford University, England

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Orcid

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First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Ahmed

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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-

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Volume

11

Article Issue

1

Related Issue

11092

Issue Date

1988-06-01

Receive Date

1988-03-09

Publish Date

1988-06-30

Page Start

70

Page End

87

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 11_Issue 1_Pages 70-87.pdf

PDF . 699.2kB

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https://bpsa.journals.ekb.eg/article_73269.html

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https://bpsa.journals.ekb.eg/service?article_code=73269

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES: V- THERMODYNAMICS OF TEMAZEPAM SOLUBILIZATION

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Article

Created At

22 Jan 2023