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INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES: IV- PHASE DIAGRAM OF TEMAZEPAM-POLYETHYLENE GLYCOL BINARY SYSTEMS

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Last updated: 25 Dec 2024

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Abstract

Differential scanning calorimetery and hot stage microscopy were used to build up temperature-composition phase diagrams for temazepam-polyethylene glycol 2000, 4000 and 6000 physical mixtures and comprecipitates. The phase diagram showed the systems to be of the monotectic type, with the monotectic species being the pure drug. Phase diagram of the drug and the investigated polyethylene glycols helped in ruling out the possibility of forming solid solution or molecular compound within the concentration range of the components investigated. Differential scanning calorimetery was also utilized for predicting the melting behaviour of temazepam and polyethylene glycols separately and as coprecipitates and physical mixture binary systems. A good correlation was found between the position of the system on the phase diagram and its dissolution rate. The highest the carrier content, the nearest the system would be to the monotectic composition, the highest the release rate of the drug. 

DOI

10.21608/bfsa.1988.73268

Authors

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B.

Last Name

Mulley

MiddleName

A.

Affiliation

School of Pharmacy, Bradford University, England

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Orcid

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First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

S.

Last Name

Ahmed

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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-

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Volume

11

Article Issue

1

Related Issue

11092

Issue Date

1988-06-01

Receive Date

1988-03-08

Publish Date

1988-06-30

Page Start

50

Page End

69

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 11_Issue 1_Pages 50-69.pdf

PDF . 682.9kB

Link

https://bpsa.journals.ekb.eg/article_73268.html

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https://bpsa.journals.ekb.eg/service?article_code=73268

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES: IV- PHASE DIAGRAM OF TEMAZEPAM-POLYETHYLENE GLYCOL BINARY SYSTEMS

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Article

Created At

22 Jan 2023