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73266

SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN PHARMACEUTICAL SECONDARY AROMATIC AMINES USING 3-METHYLBENZOTHIAZOLIN-2-ONE HYDRAZONE

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Last updated: 25 Dec 2024

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Abstract

Out of 7 pharmaceutical secondary aromatic amines tested, the oxidative coupling reaction of 3-methyl-benzothiazolin-2-one hydrazone with aromatic amines in the presence of iron (III) ammonium sulphate was applied to the determination of folic acid, primaquine phosphate and lucanthone hydrochloride. The wavelengths of maximum absorption were 530 nm (for primaquine phosphate), 580 nm (for lucanthone hydrochloride) and 660 nm (for folic acid) with molar absorptivities of 4.6 x 104, 2.3 x104 and 5.0 x 104 respectively. Beer's law was obeyed in the concentration range of 2-10 mg ml-1 (for primaquine phosphate), 2-16mg ml-1 (for lucanthone hydrochloride) and 1-10mg ml-1 (for folic acid). The proposed method was applied for the quantitative of folic acid, primaquine phosphate and licanthone hydrochloride in pure form as well as in tablets. Results of analyses were compared with the B.P. and U.S.P. procedures.   

DOI

10.21608/bfsa.1988.73266

Authors

First Name

Michael

Last Name

El-Kommos

MiddleName

E.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Kamla

Last Name

Emara

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

11

Article Issue

1

Related Issue

11092

Issue Date

1988-06-01

Receive Date

1988-02-10

Publish Date

1988-06-30

Page Start

18

Page End

28

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 11_Issue 1_Pages 18-28.pdf

PDF . 379.5kB

Link

https://bpsa.journals.ekb.eg/article_73266.html

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https://bpsa.journals.ekb.eg/service?article_code=73266

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN PHARMACEUTICAL SECONDARY AROMATIC AMINES USING 3-METHYLBENZOTHIAZOLIN-2-ONE HYDRAZONE

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Article

Created At

22 Jan 2023