Beta
ManageSearchChatDiscover
73265

FORMULATION AND EVALUATION OF BEADS AND MOLDED PREPARATIONS CONTAINING GRISEOFULVIN

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Solid dispersion containing polyethylene glycols (PEG) and different ratios of griseofulvin were made into beads and molded tablets. Beads were prepared by a newly designed technique referred to as the "dry solidification technique" (DST). This was based on dropping the molten drug-polymer mixtures from a syringe needle onto top of talc powder beds chosen as solidification substances. Molded tablets were obtained by pouring the molten mixture into a tablet triturate mold placed on aluminium foil sheets. The formed beads and tablets were examined for their physicomechanical properties and physiological availabilities. Increasing drug contents and PEG mol. Wts. were found to increase beads and tablets hardness while decreased their dissolution rates and resistance to abrasions. The mechanical properties and dissolution rates of the molded tablets were also compared with those of hardly compressed tablets containing ranges of particle size between 125-150 mm (A) and 212-250 mm (B) of corresponding solid dispersions. Molded tablets were found to be mechanically stronger than those of (A) and (B) respectively, however their dissolution rates remained almost the same. Bioavailability results of the different preparations were found to be parallel with those of their dissolution rates; so that maximum urinary excretion of the drug and higher physiological availability were observed in case of beads rather than those of molded or compressed tablets. 

DOI

10.21608/bfsa.1988.73265

Authors

First Name

F.

Last Name

Sakr

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Abd El-Gawad

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Zin El-Din

MiddleName

E.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

Volume

11

Article Issue

1

Related Issue

11092

Issue Date

1988-06-01

Receive Date

1987-12-17

Publish Date

1988-06-30

Page Start

1

Page End

17

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 11_Issue 1_Pages 1-17.pdf

PDF . 647.9kB

Link

https://bpsa.journals.ekb.eg/article_73265.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=73265

Order

1

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF BEADS AND MOLDED PREPARATIONS CONTAINING GRISEOFULVIN

Details

Type

Article

Created At

22 Jan 2023