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INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES VIII- FORMULATION OF TABLETS CONTAINING TEMAZEPAM SOLID DISPERSIONS

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Last updated: 04 Jan 2025

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Abstract

Temazepam-plyethylene glycol 6000 (PEG 6000) coprecipitates has been formulated as tablets using direct compression technique. This coprecipitation was chosen as it exhibited an optimum drug release characteristic and could be easily handled and pulverized. Differential scanning calorimetery (DSC) was utilizes to check the compatibility of Temazepam with  Avicel pH 101and magnesium stearate as well as the effect of ageing on the formulated coprecipitates, at different storage conditions. It was concluded that the drug is compatible with those tablet excipients, and n detectable change resulted from ageing. Compression of the formula containing 1:3 w/w Temazepam-PEG 6000 coprecipitates produced good quality tablets having rapid disintegration and rapid dissolution rates. Tablets of 1:7 w/w ratio were highly compact and having a lower disintegration and a lower dissolution rates. This shows the importance of optimizing the formulations by finding out the correct quantity of excipients to maintain better dissolution properties. The results obtained indicated that 1:3 w/w Temazepam-PEG 6000 coprecipitates retains its higher dissolution when compressed as tablets. Additionally, this tablets formulation helped t provide Temazepam in a high quality dosage form.

DOI

10.21608/bfsa.1989.72062

Authors

First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

-

First Name

B.

Last Name

Mulley

MiddleName

A.

Affiliation

School of Pharmacy, Bradford University, England

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City

-

Orcid

-

First Name

S.

Last Name

Ahmed

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

12

Article Issue

2

Related Issue

10952

Issue Date

1989-12-01

Receive Date

1989-09-18

Publish Date

1989-12-31

Page Start

308

Page End

324

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 12_Issue 2_Pages 308-324.pdf

PDF . 712.8kB

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https://bpsa.journals.ekb.eg/article_72062.html

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https://bpsa.journals.ekb.eg/service?article_code=72062

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES VIII- FORMULATION OF TABLETS CONTAINING TEMAZEPAM SOLID DISPERSIONS

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Article

Created At

22 Jan 2023