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72061

1H-NUCLEAR MAGNETIC RESONANCE (NMR) STUDY OF PIROXICAM-CYCLODEXTRINS INCLUSION COMPLEXES

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Last updated: 25 Dec 2024

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Abstract

A structural study of the inclusion compounds of piroxicam with cyclodextrins (a-, b- and g-) in different molar ratios was studied by means of 1H-nuclear magnetic resonance (NMR) spectroscopy. The change in the chemical shift suggested that the drug pyridine moity was included in the cavity of cyclodextrins and most of the protons shifted to lower field with increasing the concentration of cyclodextrins. Plots of the molar ratio of cyclodextrins vs. the change in the chemical shift f piroxicam indicated that a 1:1 complex was formed.

DOI

10.21608/bfsa.1989.72061

Authors

First Name

N.

Last Name

Omar

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

A.

Last Name

Ahmed

MiddleName

N.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

H.

Last Name

Ueda

MiddleName

-

Affiliation

Hoshi Institute of Pharmaceutical Sciences, Tokyo, Japan

Email

-

City

-

Orcid

-

First Name

S.

Last Name

El-Gizawy

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

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Volume

12

Article Issue

2

Related Issue

10952

Issue Date

1989-12-01

Receive Date

1989-09-12

Publish Date

1989-12-31

Page Start

298

Page End

307

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 12_Issue 2_Pages 298-307.pdf

PDF . 567.9kB

Link

https://bpsa.journals.ekb.eg/article_72061.html

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https://bpsa.journals.ekb.eg/service?article_code=72061

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

1H-NUCLEAR MAGNETIC RESONANCE (NMR) STUDY OF PIROXICAM-CYCLODEXTRINS INCLUSION COMPLEXES

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Article

Created At

22 Jan 2023