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72057

FORMULATION OF CONTROLLED-RELEASE IBUPROFEN GRANULES AND EVALUATION OF THE ANTIINFLAMMATORY ANALGESIC ACTIVITIES

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Last updated: 25 Dec 2024

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Abstract

Two kinds of granules were prepared: one. with pH-dependent Release and the other with pH-in dependent release. The former was composed of ibuprofen, celluloseacetate phthalate, ethylcellulose and microcrystalline cellulose while the latter was composed of ibuprofen, hydroxypropyl methylcellulose, ethylcellulose and corn starch. The effects of mixing ratios of the polymers; pH of the release medium, and the drug content in the granules were examined in-vitro to investigate the release characteristics. In granules with pH-dependent, the release rate was decreased with the increment of ethylcellulose and as the pH of the release medium increased. While in granules with pH-independent, the release rate was decreased as the ratio of hydroxypropyl methylcellulose (HPMC) to ethylcellulose (EC) increased Analgesic activity of four seleted formulations of the controlled release was tested by two methods using p-benzoquinone (PB2) induced withing and the hot-plate. Also the anti-inflammatory activity of these formulations was examined after oral administration of the granules by using trypan-blue dye method. Results that the formulation of ibuprofen granules pH-independent containing HPMC and EC revealed in ratio of 3:1 had a delayed onset of anti-inflammatory and analgesic action extended for four hours or more while granules of ibuprofen with pH-dependent containing 4% ethylcellulose and 2% cellulose acetate phthalate were capable of increasing analgesic against thermal stimuli for four hours whereas lower percentage protection against PBO-induced wrifhing, was observed. Statistical analysis of the results were done using student's t-test.           The pH- independent release granules were superior to the pH-dependent release granules with respect to prolonging the effective antiinflammatory action when administered orally to rats.

DOI

10.21608/bfsa.1989.72057

Authors

First Name

S.

Last Name

Safwat

MiddleName

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

El-Shanawany

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

M.

Last Name

Abdel-Rahman

MiddleName

M.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

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City

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Orcid

-

First Name

S.

Last Name

Mangoura

MiddleName

A.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Volume

12

Article Issue

2

Related Issue

10952

Issue Date

1989-12-01

Receive Date

1989-05-09

Publish Date

1989-12-31

Page Start

240

Page End

265

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 12_Issue 2_Pages 240-265.pdf

PDF . 893.3kB

Link

https://bpsa.journals.ekb.eg/article_72057.html

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https://bpsa.journals.ekb.eg/service?article_code=72057

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION OF CONTROLLED-RELEASE IBUPROFEN GRANULES AND EVALUATION OF THE ANTIINFLAMMATORY ANALGESIC ACTIVITIES

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Article

Created At

22 Jan 2023