Beta
ManageSearchChatDiscover
72053

INTERACTION OF TEMAZEPAM WITH HYDROPHILIC MACROMOLECULES VI- PREPARATION, DISSOLUTION CHARACTERISTICS AND AGEING OF TEMAZEPAM SOLID DISPERSIONS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Temazepam solid dispersions were prepared using the solvent and the fusion methods with certain hydrophilic carriers including polyethylene glycol 6000 (PEG 6000),Murj 52, polyvinyl pyrrolidone 10000 (PVP 10000), and polyvinyl pyrrolidone 40000 (PVP 40000). It was found that the solvent method is preferable than the fusion method.           Thin layer chromatographic investigations revealed that three was no chemical degradation of the drug or the carriers through processing.           Infrared analysis revealed that there was no evidence for complexation between temazepam and the investigated carriers nor decomposition of the drug.           Differential scanning calorimetery (DSC) investigations illustrated that the drug present in the coprecipitates in the amorphous form in the fresh samples as well as the aged-ones. HPLC in the aged samples proved no drug degradation.

DOI

10.21608/bfsa.1989.72053

Authors

First Name

A.

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

B.

Last Name

Mulley

MiddleName

A.

Affiliation

School of Pharmacy, Bradford University, England

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Ahmed

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

12

Article Issue

2

Related Issue

10952

Issue Date

1989-12-01

Receive Date

1989-02-06

Publish Date

1989-12-31

Page Start

175

Page End

194

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 12_Issue 2_Pages 175-194.pdf

PDF . 805.8kB

Link

https://bpsa.journals.ekb.eg/article_72053.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=72053

Order

1

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INTERACTION OF TEMAZEPAM WITH HYDROPHILIC MACROMOLECULES VI- PREPARATION, DISSOLUTION CHARACTERISTICS AND AGEING OF TEMAZEPAM SOLID DISPERSIONS

Details

Type

Article

Created At

22 Jan 2023