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71463

POLYMERIC FILMS AS TOPICAL DRUG DELIVERY SYSTEM FOR ANTIBIOTICS AND LOCAL ANAESTHETICS

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Last updated: 25 Dec 2024

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Abstract

The utilization of cellulose acetate butyrate films as a topical drug delivery system for chloramphenicol and lignocaire hydrochloride was investigated. The effect of plasticizers and drug concentration on the In-Vitro release of drug as well as on the physicomechanical properties of the films have been examined. The drug release data were kinetically studied and were found to follow the diffusion controlled release model. The incorporation of either dimethyl phthalate or diethyl phthalate afforded the optimum rates of release and optimum water vapor transmission rates and exhibited acceptable mechanical properties. The release rate of chloramphenicol was found markedly higher than that of lignocaine hydrochloride. The effect of plasticizers on drug release is more pronounced in case f water insoluble drug than the water soluble one.

DOI

10.21608/bfsa.1989.71463

Authors

First Name

S.

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

E.

Last Name

Hafez

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

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Orcid

-

First Name

H.

Last Name

El-Monem

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

lbrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

Orcid

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Volume

12

Article Issue

1

Related Issue

10887

Issue Date

1989-06-01

Receive Date

1989-03-15

Publish Date

1989-06-30

Page Start

152

Page End

172

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 12_Issue 1_Pages 152-172.pdf

PDF . 634.7kB

Link

https://bpsa.journals.ekb.eg/article_71463.html

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https://bpsa.journals.ekb.eg/service?article_code=71463

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

POLYMERIC FILMS AS TOPICAL DRUG DELIVERY SYSTEM FOR ANTIBIOTICS AND LOCAL ANAESTHETICS

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Article

Created At

22 Jan 2023