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71462

CORRELATION BETWEEN GASTRIC IRRITANCY AND BIOAVAILABILITY OF INDOMETHACIN MICROSPHERES

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Last updated: 25 Dec 2024

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Abstract

Indomethacin microspheres were prepared by an emulsion solvent evaporation method. Ethylcellulose was used as the matrix material at 1:1 drug/polymer ratio. The prepared microspheres was tested for drug content, dissolution characteristics, anti-inflammatory effect in rats and for their possible gastric effect in rabbits .A controlled release pattern of the medicament was found to be existed from the prepared microspheres. The prepared microspheres gave an anti-inflammatory effect in rats as that produced by the intact medicament. Histological examination of rabbit's stomach proved the superiority of the tested microsphere over the intact drug.

DOI

10.21608/bfsa.1989.71462

Authors

First Name

S.

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

H.

Last Name

El-Monem

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Moustafa

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt

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-

City

-

Orcid

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Volume

12

Article Issue

1

Related Issue

10887

Issue Date

1989-06-01

Receive Date

1989-03-15

Publish Date

1989-06-30

Page Start

136

Page End

151

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 12_Issue 1_Pages 136-151.pdf

PDF . 579.7kB

Link

https://bpsa.journals.ekb.eg/article_71462.html

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https://bpsa.journals.ekb.eg/service?article_code=71462

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9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CORRELATION BETWEEN GASTRIC IRRITANCY AND BIOAVAILABILITY OF INDOMETHACIN MICROSPHERES

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Article

Created At

22 Jan 2023