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71458

RELEASE STUDY OF DEXAMETHASONE FROM DIFFERENT OINTMENT BASES

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Last updated: 04 Jan 2025

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Abstract

The effect of various additives on the release of dexamethazone from different ointment bases was investigated. It was found that the rate of dexamethazone release was greater from water-soluble base and oil-in-water emulsion ointment base than from oleaginous, absorption or water-in-oil emulsion bases. Propylene glycol followed by glycerin exhibited the best effect on the amount of drug release with the different concentrations used. The incorporation of water-in-oil emulsion base decreased the rate of drug release (even less than the control) than any of the other additives. It was also concluded that the best release of dexamethazone was obtained from the bases which were of similar nature to the diffusion medium. Other factors such as the characteristics of bases and the additives as well as their effect upon the solubility of the drug in the mixture may play a part.  

DOI

10.21608/bfsa.1989.71458

Authors

First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

El-Shanawany

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

12

Article Issue

1

Related Issue

10887

Issue Date

1989-06-01

Receive Date

1989-01-11

Publish Date

1989-06-30

Page Start

90

Page End

102

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 12_Issue 1_Pages 90-102.pdf

PDF . 438.1kB

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https://bpsa.journals.ekb.eg/article_71458.html

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https://bpsa.journals.ekb.eg/service?article_code=71458

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

RELEASE STUDY OF DEXAMETHASONE FROM DIFFERENT OINTMENT BASES

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Article

Created At

22 Jan 2023