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71456

IN-VITRO AND IN-VIVO STUDIES ON OPHTHALMIC PREPARATIONS OF XYLOCAINE HYDROCHLORIDE

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Last updated: 04 Jan 2025

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Abstract

A number of both hydrophilic and lipophilic surface active agents was employed for preparing simple o/w and multiple w/o/w emulsion systems. The dynamic dialyses 06 xylocaine HCl from its aqueous, micellar solutions and o/w as well as w/o/w emulsion system were studied. The transfer of xylocaine HCl across standard cellophane membrane was fund to follow the diffusion system were controlled mechanism. The data revealed that, the nature of surfactant and emulsion type had a significant role in diffusion of the drug molecules. Generally, the release pattern of the drug from micellar solution or emulsion systems was less than that of the control. In a blind-controlled clinical study, four coded w/o/w and two coded o/w emulsions of 2.5% xylocaine HCl were compared with an aqueous solution of the drug at the same concentration. The longest mean of surface anaesthetic duration, 9,8, minutes was attained with w/o/w emulsion formed of span 60 as a lipophilic emulsifier and Myrj 52 as a hydrophilic one. The clinical application of emulsion formulations in human eyes was found to prolong the mean anaesthetic duration, decrease the eye irritation and improve the performance of the needed clinical manoeuvres.

DOI

10.21608/bfsa.1989.71456

Authors

First Name

S.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

A.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Hasan

MiddleName

A.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

12

Article Issue

1

Related Issue

10887

Issue Date

1989-06-01

Receive Date

1988-12-18

Publish Date

1989-06-30

Page Start

68

Page End

89

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 12_Issue 1_Pages 68-89.pdf

PDF . 684.1kB

Link

https://bpsa.journals.ekb.eg/article_71456.html

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https://bpsa.journals.ekb.eg/service?article_code=71456

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IN-VITRO AND IN-VIVO STUDIES ON OPHTHALMIC PREPARATIONS OF XYLOCAINE HYDROCHLORIDE

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Article

Created At

22 Jan 2023