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71454

MODIFYING EFFECTS OF POLYOXYETHYLENE STEARATES ON THE RATE OF ACID-CATALYZED HYDROLYSIS OF ACETYLSALICYLIC ACID

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Last updated: 04 Jan 2025

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Abstract

The hydrolysis of acetylsalicylic acid, ASA, in buffered solution of Polyoxyethylene stearates (Myrj 52, Myrj 53,and Myrj 59) has been studied at 37°C and over a pH range 1 through 2. The observed rate constant, Kobs, for ASA was found to be reduced markedly with an increase in Myrj concentration. The distribution coefficient of ASA between the micellar and pseudo aqueous phases has been estimated. It was found to be parallel with both the length of POE chain and the hydrogen ion concentration. The data revealed that the hydrolysis of ASA occurred mainly in the bulk aqueous phase, but at lower pH value, the contribution of hydrogen ion catalyzed reaction within the micelles becomes significant. The hydrolytic rate constant for ASA within the micelles, Km, has been calculated and was found to increase in the following ranked order: Myrj 52 > Myrj 53 > Myrj 59.

DOI

10.21608/bfsa.1989.71454

Authors

First Name

S.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

A.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

M.

Last Name

Abd-El-Mohsen

MiddleName

G.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

12

Article Issue

1

Related Issue

10887

Issue Date

1989-06-01

Receive Date

1988-11-29

Publish Date

1989-06-30

Page Start

52

Page End

67

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 12_Issue 1_Pages 52-67.pdf

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https://bpsa.journals.ekb.eg/article_71454.html

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https://bpsa.journals.ekb.eg/service?article_code=71454

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

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https://bpsa.journals.ekb.eg/

MainTitle

MODIFYING EFFECTS OF POLYOXYETHYLENE STEARATES ON THE RATE OF ACID-CATALYZED HYDROLYSIS OF ACETYLSALICYLIC ACID

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Article

Created At

22 Jan 2023