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70586

PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES

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Last updated: 25 Dec 2024

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Abstract

Hydroxyzine is a piperazine derivative recommended for treatment of anxiety. The drug was formulated in suppository forms using different types of fatty, emulsion and water soluble bases. Non ionic surfactants as well as aerosils were used as formulating additives. The drug release from the formulating bases as well as the tranquilizing potency in mice were evaluated. It was found that formulations which afford the higher release rates in the in-vitro study, give also the more pronounced tranquilizing effect in the animal testing.

DOI

10.21608/bfsa.1990.70586

Authors

First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

H.

Last Name

Sayed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

-

Orcid

-

First Name

S.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

-

Orcid

-

First Name

A.

Last Name

Gomea

MiddleName

A.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

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-

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-

Orcid

-

First Name

A.

Last Name

Shaker

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

13

Article Issue

2

Related Issue

10752

Issue Date

1990-12-01

Receive Date

1991-04-02

Publish Date

1990-12-31

Page Start

265

Page End

280

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 2_Pages 265-280.pdf

PDF . 570.9kB

Link

https://bpsa.journals.ekb.eg/article_70586.html

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https://bpsa.journals.ekb.eg/service?article_code=70586

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES

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Article

Created At

22 Jan 2023