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70582

RELEASE CHARACTERISTICS OF CAFFEINE AND MEBEVERINE HYDROCHLORIDE FROM ISOPROPYL MYRISTATE MULTIPLE EMULSIONS

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Last updated: 25 Dec 2024

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Abstract

Double emulsions (w/o/w) were prepared by two steps emulsification procedure using isopropyl myristate as the oily phase. The influence of the inner aqueous phase volume and emulsifier concentration on the release characteristics of either caffeine or mebeverine hydrochloride from the prepared emulsions was studied. For the purpose of comparison, the release of each drug from either o/w or w/o emulsion was investigated. The results showed that the release of both drugs from w/o/w emulsions was independent on the inner aqueous phase volume. The release of mebeverine hydrochloride was sustained from either w/o/w or w/o emulsions while that of caffeine was not significantly retarded as indicated by the amount released after 24 hours. Increasing the concentration of the hydrophilic emulsifier (Tween 20) had a little effect on the release of both drugs from w/o/w emulsions. On the other hand, the release of mebeverine hydrochloride was more prolonged on increasing the concentration of the lipophilic emulsifier (Span 80), while the release of caffeine was not significantly retarded.

DOI

10.21608/bfsa.1990.70582

Authors

First Name

M.

Last Name

Mohamed

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

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City

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Orcid

-

First Name

F.

Last Name

Ghazy

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Mahdy

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Gad

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

-

City

-

Orcid

-

Volume

13

Article Issue

2

Related Issue

10752

Issue Date

1990-12-01

Receive Date

1990-12-18

Publish Date

1990-12-31

Page Start

247

Page End

254

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 2_Pages 247-254.pdf

PDF . 317.2kB

Link

https://bpsa.journals.ekb.eg/article_70582.html

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https://bpsa.journals.ekb.eg/service?article_code=70582

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

RELEASE CHARACTERISTICS OF CAFFEINE AND MEBEVERINE HYDROCHLORIDE FROM ISOPROPYL MYRISTATE MULTIPLE EMULSIONS

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Article

Created At

22 Jan 2023