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70581

PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN

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Last updated: 25 Dec 2024

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Abstract

Aspirin microcapsules were prepared by the solvent evaporation method. Ethylcellulose was used as the coating material at 18:2, 17:3 and 16:4 core : coat ratios. The prepared microcapsules were separated into sieve fractions. Each fraction was evaluated for drug content and dissolution characteristics. Scaling-up was developed to evaluate the adopted microencapsulation method for large scale production. The adopted method was simple, efficient and reproducible. A prolonged release pattern of the drug was obtained by increasing the coat/core ratio. Larger microcapsules released aspirin at a slower rate than did smaller microcapsules. Scaling-up did not significantly affect the release characteristics of drug from the prepared microcapsules. Histological studies on the Guinea pig gastric mucosa after the oral administration of encapsulated aspirin revealed a lower incidence of this product compared to unencapsulated drug.

DOI

10.21608/bfsa.1990.70581

Authors

First Name

S.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

-

First Name

H.

Last Name

Sayed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Hafez

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

El-Sayed

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Ali

MiddleName

S.

Affiliation

Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

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Volume

13

Article Issue

2

Related Issue

10752

Issue Date

1990-12-01

Receive Date

1990-12-12

Publish Date

1990-12-31

Page Start

235

Page End

246

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 2_Pages 235-246.pdf

PDF . 641.8kB

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https://bpsa.journals.ekb.eg/article_70581.html

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https://bpsa.journals.ekb.eg/service?article_code=70581

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Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN

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Article

Created At

22 Jan 2023