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70580

IN-VITRO RELEASE CHARACTERISTICS OF PAPAVERINE HYDROCHLORIDE FROM MULTIPLE EMULSION SYSTEMS

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Last updated: 25 Dec 2024

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Abstract

A two-step emulsification procedure was adopted to prepare stable multiple emulsion of the W/O/W type. An aqueous solution of the drug and paraffin oil at ratio of 1:2 were used to prepare a W/O type primary emulsion (1st step) using blend of surfactants (HLB 3.8) at 10% concentration. While a blend of surfactants (HLB 12.3) was used as the second emulsifying agent for incorporating the prepared primary emulsion into the outer aqueous phase (1:2) to produce the final emulsion. Drug release from the prepared system was evaluated 24 hours after preparation and periodically at weekly intervals thereafter for four weeks. Multiple emulsion system, each containing either sodium chloride, sorbitol or methylcellulose were similarly prepared and evaluated for drug release thereof. Drug release from the prepared system was found to be greatly retarded in comparison with that from the corresponding aqueous solutions. The drug release rate from the prepared system, with the exception of those containing methylcellulose was slightly changed to lower values. The effect was greater at the second week testing while, a constant release pattern was found thereafter. The presence of methyl cellulose lead to a greater lowering in the release rate.

DOI

10.21608/bfsa.1990.70580

Authors

First Name

H.

Last Name

Sayed

MiddleName

Abdel-Monem

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

E.

Last Name

Hafez

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

13

Article Issue

2

Related Issue

10752

Issue Date

1990-12-01

Receive Date

1990-11-08

Publish Date

1990-12-31

Page Start

221

Page End

233

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 2_Pages 221-233.pdf

PDF . 473.0kB

Link

https://bpsa.journals.ekb.eg/article_70580.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=70580

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IN-VITRO RELEASE CHARACTERISTICS OF PAPAVERINE HYDROCHLORIDE FROM MULTIPLE EMULSION SYSTEMS

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Article

Created At

22 Jan 2023