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70576

BIOAVAILABILITY STUDIES OF THEOPHYLLINE MICROCAPSULES

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Last updated: 25 Dec 2024

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Abstract

The release of theophylline from microcapsules prepared by using different concentrations of ethylene-vinyl acetate (EVA) copolymer as a coacervation-inducing agent was investigated in simulated gastric and intestinal fluids. Also the bioavailability of theophylline from its microcapsules following oral administration in volunteers using the saliva drug concentration was investigated. The results pointed out that the higher the concentration of EVA compolymer used the more sustainment of theophylline from microcapsules. The investigation painted for a good correlation between the in-vitro release rate characteristics and the in-vivo salivary bioavailability parameters of theophylline microcapsules. The prepared theophylline microcapsules were proven to achieve excellent sustainment pattern and could be used to avoid sub-/or/super therapeutic levels of conventional theophylline products.

DOI

10.21608/bfsa.1990.70576

Authors

First Name

S.

Last Name

El-Shanawany

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

13

Article Issue

2

Related Issue

10752

Issue Date

1990-12-01

Receive Date

1990-09-17

Publish Date

1990-12-31

Page Start

195

Page End

203

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 2_Pages 195-203.pdf

PDF . 379.6kB

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https://bpsa.journals.ekb.eg/article_70576.html

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https://bpsa.journals.ekb.eg/service?article_code=70576

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

BIOAVAILABILITY STUDIES OF THEOPHYLLINE MICROCAPSULES

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Article

Created At

22 Jan 2023