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70570

FORMULATION AND EVALUATION OF TOPICAL METRONIDAZOLE

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Last updated: 25 Dec 2024

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Abstract

Formulation of metronidazole in the form of topical preparations did not take much attention. Thus, the aim of this work is to formulate metronidazole in the form of gel and ointment. Ten ointment bases were used viz., oleagenous, absorption, emulsion and water soluble bases. The rate of release of the drug from the water soluble polyethylene glycol base was the highest. The effect of some penetration enhancers e.g. dimethylsulfoxide, urea and ethanol on the release rate of the drug from the water soluble and the o/w emulsion bases was studied. For metronidazole gels, several cellulose derivatives were used viz., methylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, methocel. Eudragit RL 100 and Eudragit RS 100. The in-vitro release of the drug was maximum from methylcellulose gel followed by Eudragit RL 100. In general the in-vitro release of metronidazole from gel was higher than that from ointment bases. Preliminary clinical investigations of metronidazole in an ointment and in a gel formulae were performed. These preliminary studies were impressive but further clinical studies are required before recommending metronidazole as an effective topical therapy.

DOI

10.21608/bfsa.1990.70570

Authors

First Name

S.

Last Name

lbrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

S.

Last Name

Tous

MiddleName

Shawky

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

T.

Last Name

El-Faham

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Moubasher

MiddleName

A.

Affiliation

Department of Dermatology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

Orcid

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Volume

13

Article Issue

2

Related Issue

10752

Issue Date

1990-12-01

Receive Date

1990-09-09

Publish Date

1990-12-31

Page Start

181

Page End

194

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 2_Pages 181-194.pdf

PDF . 679.1kB

Link

https://bpsa.journals.ekb.eg/article_70570.html

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https://bpsa.journals.ekb.eg/service?article_code=70570

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF TOPICAL METRONIDAZOLE

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Article

Created At

22 Jan 2023