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70562

EVALUATION OF COMMERCIAL BENZOYL METRONIDAZOLE SUSPENSION

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Last updated: 25 Dec 2024

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Abstract

Benzoyl metronidazole is available in the Egyptian market as suspension. It was reported that its suspension is physically unstable. Hence, it is aimed in this study to evaluate marketed benzoyl metronidazole suspension. Four batches of benzoyl metronidazole suspension were evaluated for sedimentation volume, drug content, particle length distribution, dissolution rate and bioavailability of the drug. The results revealed significant differences in these parameters between and among the batches of the same brand. The commercial suspensions showed physical and chemical stability along 10 months of aging concerning the preceding parameters, except that the number of the large particles increase by aging. The in-vivo evaluation of two benzoyl metronidazole batches was performed in healthy human volunteers. A direct correlation could exist between the in-vitro dissolution characteristics and the in-vivo parameters.

DOI

10.21608/bfsa.1990.70562

Authors

First Name

S.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

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Orcid

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First Name

S.

Last Name

Tous

MiddleName

Shawky

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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-

Orcid

-

First Name

T.

Last Name

El-Faham

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

13

Article Issue

2

Related Issue

10752

Issue Date

1990-12-01

Receive Date

1990-12-08

Publish Date

1990-12-31

Page Start

159

Page End

168

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 2_Pages 159-168.pdf

PDF . 358.0kB

Link

https://bpsa.journals.ekb.eg/article_70562.html

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https://bpsa.journals.ekb.eg/service?article_code=70562

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EVALUATION OF COMMERCIAL BENZOYL METRONIDAZOLE SUSPENSION

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Article

Created At

22 Jan 2023