Beta
ManageSearchChatDiscover
70559

SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Positional isomers of dimethyl pyrazole carboxylic acid derivatives were prepared. Some of these compounds showed variable binding capacities towards Cu (II), Zn (II) and Mg (II). The most active chelators Ig and its isomer IIg showed antidotal and antiinflammatory activities higher than D-penicillamine. Both are more active in dose levels much lesser than their median lethal doses (LD50). 5(3)-Methylpyrazole-3(5)-carboxamide showed significant growth inhibition of R. solani. The other derivatives tested displayed growth stimulating activity rather than growth inhibition of the fungus.

DOI

10.21608/bfsa.1990.70559

Authors

First Name

Tarek

Last Name

Fadl

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Adel

Last Name

Youssef

MiddleName

F.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Abdel-Hamed

Last Name

Ahmed

MiddleName

N.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Hussein

Last Name

El-Bitar

MiddleName

I.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

13

Article Issue

2

Related Issue

10752

Issue Date

1990-12-01

Receive Date

1990-06-27

Publish Date

1990-12-31

Page Start

145

Page End

158

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 2_Pages 145-158.pdf

PDF . 504.9kB

Link

https://bpsa.journals.ekb.eg/article_70559.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=70559

Order

2

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES

Details

Type

Article

Created At

22 Jan 2023