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70558

POSSIBLE CNS DEPRESSANT EFFECTS OF SOME NEWLY SYNTHESIZED QUINAZOLINONE DERIVATIVES

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Last updated: 25 Dec 2024

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Abstract

In the present investigation, five recently synthesized derivatives (designated as compounds I, II, III, IV and V) of 2,3-disubstituted 4 (3H)-quinazolinone (I) were evaluated for their CNS depressant activities in mice. In the course of this study, all compounds were suspended in a 5% suspension of gum acacia in water and were injected i.p. with the test compound in a dose level of 60 mg/kg. All tested compounds were found to decrease spontaneous locomotor activity of mice. Only compound IV was found to potentiate pentobarbitone induced hypnosis. Regarding the effect on the skeletal muscle activity, quinazolinone derivatives II and III led to motor incoordination in 40% of mice. Out of the five tested compounds, compounds I, II and IV resulted in an increase in the mean survival time of strychnine-injected mice and a greater protection against death in these animals. However, the anticonvulsant effects exerted by quinazolinone was less efficient than those produced by phenobarbitone. In conclusion, quinazolinone compounds II and IV are more likely to be the most potent as CNS depressant compounds, whereas compound V appears to be the least efficient one.

DOI

10.21608/bfsa.1990.70558

Authors

First Name

M.

Last Name

Abdel-Rahman

MiddleName

M.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Eqypt

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City

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Orcid

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First Name

S.

Last Name

Mangoura

MiddleName

A.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Eqypt

Email

-

City

-

Orcid

-

First Name

H.

Last Name

El-Bitar

MiddleName

I.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Eqypt

Email

-

City

-

Orcid

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Volume

13

Article Issue

2

Related Issue

10752

Issue Date

1990-12-01

Receive Date

1989-11-13

Publish Date

1990-12-31

Page Start

137

Page End

144

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 2_Pages 137-144.pdf

PDF . 377.5kB

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https://bpsa.journals.ekb.eg/article_70558.html

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https://bpsa.journals.ekb.eg/service?article_code=70558

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

POSSIBLE CNS DEPRESSANT EFFECTS OF SOME NEWLY SYNTHESIZED QUINAZOLINONE DERIVATIVES

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Article

Created At

22 Jan 2023