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70554

BIOAVAILABILITY OF CARBACHOL CHLORIDE FROM DIFFERENT GEL FORMULATIONS

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Last updated: 25 Dec 2024

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Abstract

The in vitro release of carbachol chloride, a cholinomimetic drug, from different ophthalmic gel-formulations has been investigated. The release data were found to be in favour of the diffusion controlled mechanism. The effect of viscosity on the release pattern has been also studied. The amount of the drug diffused from the aqueous solution of the drug was found to decrease with an increase in the solution viscosity. On the other hand, the viscosity did not affect the release rate when the drug was formulated in gels. The effect of different gel formulations on the drug activity, a decrease in the intraocular pressure, IOP, was studied on human patients, It was found that the incorporation of the drug into hydrophilic gels resulted in an improvement of its activity. The parameters of drug activity: area above time curve; maximum drug response and time of maximum response. The statistical analysis of the data obtained was assessed. A correlation between the in vitro and in vivo data has been deduced.

DOI

10.21608/bfsa.1990.70554

Authors

First Name

S.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

A.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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-

Orcid

-

First Name

M.

Last Name

Abd El-Mohsen

MiddleName

G.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

13

Article Issue

1

Related Issue

10748

Issue Date

1990-06-01

Receive Date

1990-05-29

Publish Date

1990-06-30

Page Start

125

Page End

133

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 1_Pages 125-133.pdf

PDF . 422.6kB

Link

https://bpsa.journals.ekb.eg/article_70554.html

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https://bpsa.journals.ekb.eg/service?article_code=70554

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14

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

BIOAVAILABILITY OF CARBACHOL CHLORIDE FROM DIFFERENT GEL FORMULATIONS

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Article

Created At

22 Jan 2023