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70553

IN VITRO RELEASE OF SULCONAZOLE NITRATE FROM OINTMENT BASES

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Last updated: 25 Dec 2024

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Abstract

The release rate of sulconazole nitrate, a new antimycotic drug, from 16 ointment formulations has been assessed. The effect of two liquid additives, viz, water and dimethyl sulfoxide (DMSO) on the release rate was investigated. The most enhancing effect was, by far, exhibited by DMSO and was found to be dependent on the additive concentration. This enhancing effect was accounted for the increase in the drug solubility in presence of DMSO rather than water. As regard to the effect of ointment base on the release pattern of the drug, water soluble bases were the superior. This observation is attributed to the fact that sulconazole nitrate is freely soluble in those water soluble bases. The difference in the release rate values exhibited when the drug was formulated in the water soluble bases is almost due to the change in formulations viscosities. It is worthy to note that the release pattern of sulconazole nitrate from all the tested ointment formulations was in agreement with the well known Higuchi diffusional model.

DOI

10.21608/bfsa.1990.70553

Authors

First Name

S.

Last Name

Ismail

MiddleName

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

A.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

M.

Last Name

Abd El-Mohsen

MiddleName

G.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

13

Article Issue

1

Related Issue

10748

Issue Date

1990-06-01

Receive Date

1990-05-03

Publish Date

1990-06-30

Page Start

115

Page End

123

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 1_Pages 115-123.pdf

PDF . 371.7kB

Link

https://bpsa.journals.ekb.eg/article_70553.html

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https://bpsa.journals.ekb.eg/service?article_code=70553

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13

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IN VITRO RELEASE OF SULCONAZOLE NITRATE FROM OINTMENT BASES

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Article

Created At

22 Jan 2023