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70551

FORMULATION OF RIFAMPICIN SUPPOSITORIES

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Last updated: 25 Dec 2024

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Abstract

Rifampicin is a powerful bactericidal antitubercular drug. The drug was formulated as suppositories. Witepsol H12 was used as the formulating base. Certain other bases as witepsol H15 and W35 and Massa estarinum B and BC as well as cacao butter replaced witepsol H12. Non-ionic surfactants with different chemical compositions, different HLB values as well as different physical and solubility properties were incorporated into witepsol H12 at 5% concentration, of the tested surfactants were polysorbates. Spans, Myrjs and Brijs. Drug dialysis into saline solution at 37°C was studied through cellophane membrane, of the tested bases. Witepsols gave the highest dialysis rates. Polysorbates proved to be superior among the tested surfactants.

DOI

10.21608/bfsa.1990.70551

Authors

First Name

H.

Last Name

Sayed

MiddleName

Abdel-Monem

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

A.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

13

Article Issue

1

Related Issue

10748

Issue Date

1990-06-01

Receive Date

1990-04-02

Publish Date

1990-06-30

Page Start

97

Page End

102

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 13_Issue 1_Pages 97-102.pdf

PDF . 244.1kB

Link

https://bpsa.journals.ekb.eg/article_70551.html

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https://bpsa.journals.ekb.eg/service?article_code=70551

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION OF RIFAMPICIN SUPPOSITORIES

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Article

Created At

22 Jan 2023