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70378

IMPROVEMENT OF DISSOLUTION BEHAVIOR OF TEMAZEPAM

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Last updated: 25 Dec 2024

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Abstract

The interaction between temazepam and b-cyclodextrin (b-CD) or hydroxypropyl b-cyclodextrin (HPb-CD) was studied in aqueous solution. The attempts made to obtain temazepam-cyclodextrin complexes in the solid state through freeze drying or slow evaporation under nitrogen of equimolar solutions of temazepam-CD failed to separate these inclusion compounds. On the other hand, co-grinding of temazepam with b-CD or HPb-CD although showed no evidence of formation of inclusion complexes, yet gave rise to very fast dissolution compared to non-treated temazepam or its physical mixtures with CD. Furthermore, the co-grinding of temazepam with Avicel PH 101 (microcrystalline ,cellulose) improved temazepam dissolution to nearly the same extent as those of b-CD or HPb- CD.

DOI

10.21608/bfsa.1991.70378

Authors

First Name

S.

Last Name

Saleh

MiddleName

I.

Affiliation

Department. of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Ahmed

MiddleName

M.

Affiliation

Department. of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

-

Orcid

-

First Name

J.

Last Name

Aiache

MiddleName

M.

Affiliation

Laboratoire de Biopharmacie, Faculte de.Pharmacie, B.P. 38, 63001 Clermont-ferrand Cedex, France

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Volume

14

Article Issue

1

Related Issue

10715

Issue Date

1991-12-01

Receive Date

1991-10-09

Publish Date

1991-12-31

Page Start

95

Page End

102

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 14_Issue 1_Pages 95-102.pdf

PDF . 305.8kB

Link

https://bpsa.journals.ekb.eg/article_70378.html

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https://bpsa.journals.ekb.eg/service?article_code=70378

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IMPROVEMENT OF DISSOLUTION BEHAVIOR OF TEMAZEPAM

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Article

Created At

22 Jan 2023