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70377

FORMULATION AND EVALUATION OF SOME TOPICAL ANTIMYCOTICS 3- EFFECT OF PROMOTORS ON THE IN VITRO AND IN VIVO EFFICACY OF CLOTRIMAZOLE OINTMENT

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Last updated: 25 Dec 2024

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Abstract

Dimethyl sulphoxide (DMSO), linoleic acid (LOA) and propylene glycol (PG) glyceryl monostearate (GMS), dioctyl sodium sulphosuccinate and Brij 35 were tested as enhancers for clotrimazole permeation. The results revealed that, incorporation of the tested promotors in the oleagenous base increased the in vitro release rate of the drug and also its antimycotic activity against Candida albicans. Contrast results were obtained for the water soluble base. The amount of clotrimazole determined in rabbit skin, was more pronounced when the additives were incorporated in the water soluble base. The histological studies of rabbit skin, showed variable degrees of penetration and no harmful changes of the skin tissues were observed.

DOI

10.21608/bfsa.1991.70377

Authors

First Name

S.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

E.

Last Name

Hafez

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

El-Shanawany

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

-

First Name

I.

Last Name

El-Gibaly

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

-

Orcid

-

First Name

S.

Last Name

Ali

MiddleName

A.

Affiliation

Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Volume

14

Article Issue

1

Related Issue

10715

Issue Date

1991-12-01

Receive Date

1991-07-18

Publish Date

1991-12-31

Page Start

82

Page End

94

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 14_Issue 1_Pages 82-94.pdf

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https://bpsa.journals.ekb.eg/article_70377.html

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https://bpsa.journals.ekb.eg/service?article_code=70377

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF SOME TOPICAL ANTIMYCOTICS 3- EFFECT OF PROMOTORS ON THE IN VITRO AND IN VIVO EFFICACY OF CLOTRIMAZOLE OINTMENT

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Article

Created At

22 Jan 2023