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70376

A STUDY OF THE INCLUSION COMPLEX OF AMOBARBITAL WITH HEPTAKIS (2,6-DI-O-METHYL)--CYCLODEXTRIN

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Last updated: 25 Dec 2024

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Abstract

The inclusion complex of amobarbital, a hypnotic and sedative agent, with heptakis (2,6-di-o-methyl)-b-cyclodextrin (DMCD) in aqueous solution and in the solid phase was studied by the solubility method, UV spectroscopy, infrared spectroscopy (IR) ,differential scanning calorimetry (DSC) and X-ray diffractometry. The inclusion complex was confirmed to be 1: 1. The solid complex of amobarbital with DMCD in 1:1 molar ratio was prepared by coprecipitation method. The solubility and dissolution characteristics of the solid complex in water at 37±1 °C were examined. The complex formation constant, Kc, was calculated from the slope and intercept of the AL solubility diagram (950 M-1). The dissolution rate of amobarbital was significantly enhanced by the complexation with DMCD specially in the initial period of dissolution. The hypnotic effect of amobarbital and its complex given orally to mice was evaluated.  The inclusion complex, showed a decrease in the onset of action and an increase in the duration of hypnotic effect.

DOI

10.21608/bfsa.1991.70376

Authors

First Name

M.

Last Name

Abd El-Mohsen

MiddleName

G.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

H.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Analytical Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

14

Article Issue

1

Related Issue

10715

Issue Date

1991-12-01

Receive Date

1991-05-13

Publish Date

1991-12-31

Page Start

74

Page End

81

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 14_Issue 1_Pages 74-81.pdf

PDF . 339.3kB

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https://bpsa.journals.ekb.eg/article_70376.html

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https://bpsa.journals.ekb.eg/service?article_code=70376

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

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https://bpsa.journals.ekb.eg/

MainTitle

A STUDY OF THE INCLUSION COMPLEX OF AMOBARBITAL WITH HEPTAKIS (2,6-DI-O-METHYL)--CYCLODEXTRIN

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Article

Created At

22 Jan 2023