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70375

DESIGN OF SUSTAINED RELEASE FORMULATIONS OF SALBUTAMOL II- CLAY SORBATE SYSTEMS

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Last updated: 25 Dec 2024

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Abstract

Salbutamol is an effective drug in the treatment of bronchial asthma. The adsorption of salbutamol onto various clays viz., veegum HV, bentonite and magnesium trisilicate was investigated. The optimal conditions for loading the drug onto the clays were determined. The drug release from its sorbates indicates the need for a diffusion barrier to modify the drug release profile. Cellulose acetate butyrate at 1:1 core : coat ratio was used as a coating material. The coated drug sorbates offered an acceptable release profile of the drug. Coated sorbates prepared by using drug loaded onto veegum HV as the core were used to prepare a sustained release formulation of the drug. The formulation was tested in asthmatic patients and compared to the plain drug by measuring some pulmonary functions. The administration of the sustained release formulation twice daily gave the same or better improvement than that of the plain drug given three times a day.

DOI

10.21608/bfsa.1991.70375

Authors

First Name

H.

Last Name

Sayed

MiddleName

Abdel Monem

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

El-Sayed

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Osman

MiddleName

Hamed

Affiliation

Department of Chest, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Fathy

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

14

Article Issue

1

Related Issue

10715

Issue Date

1991-12-01

Receive Date

1991-04-10

Publish Date

1991-12-31

Page Start

61

Page End

73

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 14_Issue 1_Pages 61-73.pdf

PDF . 757.8kB

Link

https://bpsa.journals.ekb.eg/article_70375.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=70375

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7

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DESIGN OF SUSTAINED RELEASE FORMULATIONS OF SALBUTAMOL II- CLAY SORBATE SYSTEMS

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Article

Created At

22 Jan 2023