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70374

DESIGN OF SUSTAINED RELEASE FORMULATIONS OF SALBUTAMOL I- ION-EXCHANGE RESIN SYSTEMS

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Last updated: 25 Dec 2024

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Abstract

Ion-exchange resins were used in an attempt to prepare sustained release products of salbutamol. Different types of cation-exchange resins were tested namely; Amberlite IRP-69, Amberlite IR-120, Amberlite MB-l, Amberlite CG-50 and Amberlite IRC-50. The drug was loaded onto resins using the batch process. The effect of drug concentration and the resin forms on the loading capacity of resins were tested. The drug release patterns from its resinates were studied. The release rates were too high to bring about sustained action properties. The drug resinates prepared by the use of each Amberlite IRP-69 (H+ and Na+- form) and Amberlite IR-120 (Na+-form) were subjected to coating treatment adopting emulsion-solvent evaporation microencapsulation. Cellulose acetate butyrate was used as the coating material, A sustained release formulations of the prepared· microcapsules were clinically evaluated. The treatment with the sustained release formulation given twice daily was found to be clinically the same or better than of the plain drug given three times a day.

DOI

10.21608/bfsa.1991.70374

Authors

First Name

H.

Last Name

Sayed

MiddleName

Abdel Monem

Affiliation

Department of Pharmaceutics., Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

El-Sayed

MiddleName

M.

Affiliation

Department of Pharmaceutics., Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Osman

MiddleName

Hamed

Affiliation

Department of Chest, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Fathy

MiddleName

-

Affiliation

Department of Pharmaceutics., Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

14

Article Issue

1

Related Issue

10715

Issue Date

1991-12-01

Receive Date

1991-04-09

Publish Date

1991-12-31

Page Start

46

Page End

60

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 14_Issue 1_Pages 46-60.pdf

PDF . 698.9kB

Link

https://bpsa.journals.ekb.eg/article_70374.html

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https://bpsa.journals.ekb.eg/service?article_code=70374

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6

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DESIGN OF SUSTAINED RELEASE FORMULATIONS OF SALBUTAMOL I- ION-EXCHANGE RESIN SYSTEMS

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Article

Created At

22 Jan 2023