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70373

FACTORS AFFECTING CHLORDIAZEPOXIDE SOLUBILIZATION BY NON-IONIC SURFACTANTS

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Last updated: 25 Dec 2024

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Abstract

Ceratain factors affecting chlordiazepoxide solubilization in series of non-ionic surfactant solutions were investigated viz., surfactant structure, the pH, the temperature and the incorporation of certain hydroxylated organic additives. Polysorbate 80 was more efficient for the drug solubilization than polysorbate 20 and Brij 35 was more efficient than Brij 58. On the other hand Eumulgin C1000 was found to be more efficient than Eumulgin C1500 and Myrj 52 was more than Myrj 53 than Myrj 59. Increasing the pH of Eumulgin and Brij solutions caused a gradual decrease in the quantity of the drug solubilized. Nukerjee treatment was adopted to quantify the role of both the core and capsular regions of Myrj micelles in solubilizing the drug. The drug was solubilized in Eumulgin and Brij series containing 5 or 10% w/v propylene glycol, glycerol, PEG 400 and PEG 4000. Brij 35 containing 5% w/v propylene glycol was the most efficient solubilizer for chlordiazepoxide. The distribution coefficient, Km, of the drug between the micellar and aqueous phases was calculated.

DOI

10.21608/bfsa.1991.70373

Authors

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A.

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

E.

Last Name

Samy

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

14

Article Issue

1

Related Issue

10715

Issue Date

1991-12-01

Receive Date

1991-03-24

Publish Date

1991-12-31

Page Start

35

Page End

45

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 14_Issue 1_Pages 35-45.pdf

PDF . 601.8kB

Link

https://bpsa.journals.ekb.eg/article_70373.html

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https://bpsa.journals.ekb.eg/service?article_code=70373

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Original Article

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1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FACTORS AFFECTING CHLORDIAZEPOXIDE SOLUBILIZATION BY NON-IONIC SURFACTANTS

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Article

Created At

22 Jan 2023