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STUDY OF THE EFFECT OF VERAPAMIL, CHLORDIAZEPOXIDE AND THEIR COMBINATION ON SPONTANEOUS LOCOMOTOR ACTIVITY IN MICE

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Last updated: 25 Dec 2024

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Abstract

The effects of verapamil, ch1ordiazepoxide (CDX) separately or and in combination on spontaneous locomotor activity (SLMA) of mice were investigated using an activity cage apparatus. Results of the present study revealed that the i.p. injection of verapamil in three dose levels(0.3, 0.6 and 1.3 mg/kg) elicited a dose dependent decrease, both in intensity and duration, of SLMA of mice. The i.p. administration of CDX in doses of 5 and 10 mg/kg brought about a significant dose-related diminution of SLMA of mice. Verapamil, in its three levels, administered concurrently with CDX., in its two dose levels, resulted in a significant potentiation of CDX- induced inhibition of SLMA. However, This potentiation caused by verapamil was much more evident with the smaller dose level of CDX (5mg/kg), than with the higher dose level  (10 mg/kg). Available reports are in agreement with our results. These reports indicate that verapamil might have the ability to suppress ALMA of mice'· and to potentiate the CDX-induced inhibition of SLMA via different mode of action.

DOI

10.21608/bfsa.1991.70372

Authors

First Name

M.

Last Name

Abdel-Rahman

MiddleName

M.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut university, Assiut, Egypt

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Volume

14

Article Issue

1

Related Issue

10715

Issue Date

1991-12-01

Receive Date

1991-03-03

Publish Date

1991-12-31

Page Start

23

Page End

34

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 14_Issue 1_Pages 23-34.pdf

PDF . 722.4kB

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https://bpsa.journals.ekb.eg/article_70372.html

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https://bpsa.journals.ekb.eg/service?article_code=70372

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

STUDY OF THE EFFECT OF VERAPAMIL, CHLORDIAZEPOXIDE AND THEIR COMBINATION ON SPONTANEOUS LOCOMOTOR ACTIVITY IN MICE

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Article

Created At

22 Jan 2023