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70371

FORMULATION AND EVALUATION OF CLOTRIMAZOLE OINTMENT

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Last updated: 25 Dec 2024

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Abstract

The in vitro release of clotrimazole from different ointment bases was studied. The bases tested were oleagenous, absorption, water-soluble, an O/W emulsion and a W/O emulsion ointment base. The release profile agreed with the first order mechanism. Among the tested bases, the water soluble base provided the best release rate. Clotrimazole exhibited antimycotic effect against C. albicans. 'The data had confirmed the in-vitro release results and proved the superiority of the water soluble bases. The clinical evaluation was performed on patients complaining of T. circinata. Three ointment formulations of different release pattern Viz; waters soluble, O/W emulsion and an oleagenous ointment each incorporating 1% clotrimazole, were selected to conduct the clinical test. Good efficacy was obtained with 1% clotrimazole in water soluble base composed of PEG 4000 and PEG 400 (4:6).

DOI

10.21608/bfsa.1991.70371

Authors

First Name

S.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

E.

Last Name

Hafez

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

El-Shanawany

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

E.

Last Name

Abdel-Magid

MiddleName

-

Affiliation

Department of Dermatology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Orcid

-

First Name

E.

Last Name

El-Gibaly

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

14

Article Issue

1

Related Issue

10715

Issue Date

1991-12-01

Receive Date

1991-02-14

Publish Date

1991-12-31

Page Start

13

Page End

22

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 14_Issue 1_Pages 13-22.pdf

PDF . 617.5kB

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https://bpsa.journals.ekb.eg/article_70371.html

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https://bpsa.journals.ekb.eg/service?article_code=70371

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF CLOTRIMAZOLE OINTMENT

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Article

Created At

22 Jan 2023