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70370

EFFECT OF SUSPENDING AGENTS ON THE DISSOLUTION AND BIOAVAILABILITY OF AMPICILLIN

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Last updated: 25 Dec 2024

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Abstract

The effect of various suspending agents viz., Methyl cellulose, Sodium carboxymethyl cellulose, Bentonite and polyvinylpyrrolidone on the dissolution of ampicillin from its suspensions was studied. Methyl cellulose (MC) gave the best ampicillin suspensions as indicated by the highest sedimentation volume (F=0.78) while polyvinylpyrrolidone (PVP) gave the poorest suspensions (F=0.11). The effectiveness of the suspending agents decreased in the following order: MC > Bentonite > Sod. CMC > PVP. The in-vitro dissolution studies showed that all the suspending agents decreased the dissolution rate of the drug. As the suspending agents concentration was increased, the retardation effect on drug dissolution increased. The bioavailability of ampicillin from its suspensions was studied in 6 healthy volunteers by urinary excretion method. Commercial product (Penbritin) was included for comparison. Both % dose excreted and maximum excretion rate were markedly reduced except' in suspension containing Sod. CMC. However, the time for maximum excretion was not affected.

DOI

10.21608/bfsa.1991.70370

Authors

First Name

A.

Last Name

Bosela

MiddleName

A.

Affiliation

Department of Pharmaceutics, Al-Fateh University, Tripoli, Libya

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Orcid

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First Name

M.

Last Name

Treki

MiddleName

S.

Affiliation

Department of Pharmaceutics, Al-Fateh University, Tripoli, Libya

Email

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Orcid

-

First Name

M.

Last Name

Mahdy

MiddleName

A.

Affiliation

Department of Pharmaceutics, Al-Fateh University, Tripoli, Libya

Email

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City

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Orcid

-

First Name

M.

Last Name

Mohamed

MiddleName

S.

Affiliation

Department of Pharmaceutics, Al-Fateh University, Tripoli, Libya

Email

-

City

-

Orcid

-

Volume

14

Article Issue

1

Related Issue

10715

Issue Date

1991-12-01

Receive Date

1990-12-18

Publish Date

1991-12-31

Page Start

6

Page End

12

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 14_Issue 1_Pages 6-12.pdf

PDF . 394.2kB

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https://bpsa.journals.ekb.eg/article_70370.html

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https://bpsa.journals.ekb.eg/service?article_code=70370

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF SUSPENDING AGENTS ON THE DISSOLUTION AND BIOAVAILABILITY OF AMPICILLIN

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Article

Created At

22 Jan 2023