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1HNMR OF PYRAZOLES: EFFECT OF INTERACTION OF CARBAMOYL GROUP WITH ADJACENT CENTERS ON THE CHEMICAL SHIFTS OF CONCERNED PROTONS

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Last updated: 04 Jan 2025

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Abstract

The 1HNMR of a series of constitutional isomers of dimethylpyrazole carboxamides revealed the contribution of p and/or n-electrons in deshielding protons a- to CONHR group. Intermolecular hydrogen bonding with polar solvent molecules was able to affect more strongly the CONHR proton chemical shift than intramolecular. The observed pattern of d values shown by CONHR proton in the derivative R= C6H11 allowed to assign for it a trans axial conformation. Finally a regression equation was derived to draw a linear relation between the chemical shifts of CONHR protons in both isomers.

DOI

10.21608/bfsa.1992.70220

Authors

First Name

Tarek

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Medicinal Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71516, A.R. Egypt

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Orcid

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First Name

Adel

Last Name

Youssef

MiddleName

F.

Affiliation

Department of Medicinal Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71516, A.R. Egypt

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Orcid

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First Name

Abd-El-Hamid

Last Name

Ahmed

MiddleName

N.

Affiliation

Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71516, A.R. Egypt

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Volume

15

Article Issue

1

Related Issue

10665

Issue Date

1992-12-01

Receive Date

1992-08-17

Publish Date

1992-12-31

Page Start

100

Page End

105

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 15_Issue 1_Pages 100-105.pdf

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https://bpsa.journals.ekb.eg/article_70220.html

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https://bpsa.journals.ekb.eg/service?article_code=70220

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

1HNMR OF PYRAZOLES: EFFECT OF INTERACTION OF CARBAMOYL GROUP WITH ADJACENT CENTERS ON THE CHEMICAL SHIFTS OF CONCERNED PROTONS

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Article

Created At

22 Jan 2023