Beta
ManageSearchChatDiscover
70219

EFFECT OF CELLULOSIC POLYMERS ON THE PHYSICAL PROPERTIES AND DISSOLUTION OF IBUPROFEN GRANULES

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Ibuprofen sustained release granules were prepared using ce11ulosic polymers including, ethy1cel1u1ose 20, hydroxypropyl methyl cellulose (Pharmacoat 606) and hydroxypropyl methy1 cellulose phthalate (HP 55 F). Polyvinyl pyrro1idone (PVP) was used also as a granu1ating agent for comparison. Increasing the concentration of the granulating agents investigated lead to retardation of the drug release rate except for Pharmacoat 606. Ethyl cellulose 20 in 5% w/v concentration proved to be the best retardant for ibuprofen release rate from the prepared granules. The physical properties of ibuprofen powder, ibuprofen granules as a control and ibuprofen granules granulated with 5% w/v ethyl cellulose 20 were examined and including the size range, the angle of repose, the flow rate, the bulk density, the Hausner factor, the compressibi1ity, the friability and the parameters of Kawakita. The effect of particle size of ibuprofen granules prepared by 5% w/v ethyl cellulose 20 as a granulating agent was checked. Increasing the particle size of the prepared granules lead to more prolongation in ibuprofen release rate.

DOI

10.21608/bfsa.1992.70219

Authors

First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Stamm

MiddleName

-

Affiliation

Faculty of Pharmacy, Louis Pasteur University, France

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Abdel Rahman

MiddleName

I.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Samy

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

15

Article Issue

1

Related Issue

10665

Issue Date

1992-12-01

Receive Date

1992-07-15

Publish Date

1992-12-31

Page Start

89

Page End

99

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 15_Issue 1_Pages 89-99.pdf

PDF . 508.5kB

Link

https://bpsa.journals.ekb.eg/article_70219.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=70219

Order

10

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF CELLULOSIC POLYMERS ON THE PHYSICAL PROPERTIES AND DISSOLUTION OF IBUPROFEN GRANULES

Details

Type

Article

Created At

22 Jan 2023