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70218

SYNTHESIS OF CERTAIN 8-[2-HYDROXY-3-(SUBSTITUTEDAMINO)PROPOXY]QUINOLINES AS B-ADRENERGIC BLOCKING AGENTS

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Last updated: 04 Jan 2025

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Abstract

The reaction of 8-hydroxyquinoline I with epichlorohydrin in the presence of potassium carbonate yielded a mixture of the epoxide II and the chlorohydrin III. The reaction of certain amines with a mixture of II and III afforded 8-[2-hydroxy-3-(substitutedamino) propoxy] quinoline IVa-h. The structure of the synthesized compounds was established by microanalyses and 1H-NMR spectra. The hydrolytic rate constants in aqueous solution at pH 7 and pH 12 were determined using HPLC technique.

DOI

10.21608/bfsa.1992.70218

Authors

First Name

Abd-El Hamid

Last Name

Ahmed

MiddleName

N.

Affiliation

Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

15

Article Issue

1

Related Issue

10665

Issue Date

1992-12-01

Receive Date

1992-02-25

Publish Date

1992-12-31

Page Start

83

Page End

88

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 15_Issue 1_Pages 83-88.pdf

PDF . 232.0kB

Link

https://bpsa.journals.ekb.eg/article_70218.html

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https://bpsa.journals.ekb.eg/service?article_code=70218

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS OF CERTAIN 8-[2-HYDROXY-3-(SUBSTITUTEDAMINO)PROPOXY]QUINOLINES AS B-ADRENERGIC BLOCKING AGENTS

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Article

Created At

22 Jan 2023