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70215

PREPARATION AND EVALUATION OF CLONAZEPAM SOLID DISPERSIONS

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Last updated: 04 Jan 2025

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Abstract

Preparation of clonazepam solid dispersions was carried out using certain hydrophilic carriers including polyethylene glycol 2000, (PEG 2000) polyethylene glycol 4000 (PEG 4000), polyethylene glycol 6000 (PEG 6000), polyvinyl pyrrolidone 44000 (PVP 44000), Myrj 52,  Myrj 53 and Myrj 59. The solvent method was adopted for the preparation of the investigated solid dispersions which were subjected to ultraviolet, differential scanning calorimetry (DSC) and dissolution evaluation. It was found that dissolution enhancement was obtained from the prepared co-precipitates compared to the drug alone. The type of the carriers used, their chemical natures and their molecular weights have pronounced effects on the dissolution rate of the drug.

DOI

10.21608/bfsa.1992.70215

Authors

First Name

A.

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Saleh

MiddleName

I.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

S.

Last Name

Ahmed

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

-

First Name

G.

Last Name

Mahrous

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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Volume

15

Article Issue

1

Related Issue

10665

Issue Date

1992-12-01

Receive Date

1991-10-08

Publish Date

1992-12-31

Page Start

49

Page End

56

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 15_Issue 1_Pages 49-56.pdf

PDF . 311.6kB

Link

https://bpsa.journals.ekb.eg/article_70215.html

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https://bpsa.journals.ekb.eg/service?article_code=70215

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREPARATION AND EVALUATION OF CLONAZEPAM SOLID DISPERSIONS

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Article

Created At

22 Jan 2023