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70208

SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES

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Last updated: 25 Dec 2024

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Abstract

The synthesis of certain imidazo[4,5-b]pyridine derivatives namely;3-(p-(un)substitutedphenacyl) imidazo[4,5-b]pyridin-2-ones, their ketoximes and 1,3-bis(p-(un)substitutedphenacyl)imidazo[4,5-b]pyridin-2-ones, were under-taken. In addition the synthesis of a series of 2-methylaminoimidazo[4,5-b]pyridines and their corresponding ketoximes are discussed. Some of the synthesized imidazo[4,5-b]-pyridin-2-ones derivatives showed reasonable analgesic activity in comparison to Aspirin and Indomethacin. Compounds of 2-methylaminoimidazo [4,5-b] pyridines and their corresponding ketoximes have been tested for their anthelmintic activity against Ascaris Vitulorum of cattle in comparison to Mebendazole.

DOI

10.21608/bfsa.1992.70208

Authors

First Name

M.

Last Name

El-Gendy

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

H.

Last Name

Farag

MiddleName

H.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Abmed

MiddleName

N.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

J.

Last Name

Stedman

MiddleName

R.

Affiliation

School of Pharmacy, Temple University, Philadelphia, USA

Email

-

City

-

Orcid

-

First Name

G.

Last Name

Alkaramany

MiddleName

S.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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Volume

15

Article Issue

1

Related Issue

10665

Issue Date

1992-12-01

Receive Date

1990-12-16

Publish Date

1992-12-31

Page Start

9

Page End

21

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 15_Issue 1_Pages 9-21.pdf

PDF . 513.2kB

Link

https://bpsa.journals.ekb.eg/article_70208.html

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https://bpsa.journals.ekb.eg/service?article_code=70208

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES

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Article

Created At

22 Jan 2023