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70203

A THIRD DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR THE IN VITRO DETERMINATION OF AMINOGLUTETHIMIDE AND ITS N-ACETYL METABOLITE IN HUMAN PLASMA

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Last updated: 25 Dec 2024

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Abstract

Rapid third derivative (D) spectrophotometric analysis procedures are described for the determination of aminoglutethimide and its N-acetyl metabolite in human plasma. The developed procedures minimize the mutual interference between these compounds and allow their determination without a previous extraction step. Aminoglutethimide and N-acetylaminoglutethimide are determined through the measurement of D3 amplitudes at 266 and 256 nm, respectively. Relative standard deviations for the assay of both compounds were less than 1.24%. Recoveries ranged from 97.2 to 99.8% for aminoglutethimide and from 97.0 to 99.4% for N-acetylaminoglutethimide.

DOI

10.21608/bfsa.1993.70203

Authors

First Name

M.

Last Name

Abdel-Khalek

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt

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Orcid

-

First Name

M.

Last Name

Mahrous

MiddleName

S.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt

Email

-

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-

Orcid

-

First Name

H.

Last Name

Daabees

MiddleName

G.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt

Email

-

City

-

Orcid

-

First Name

Y.

Last Name

Beltagy

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt

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Volume

16

Article Issue

2

Related Issue

10642

Issue Date

1993-12-01

Receive Date

1993-06-05

Publish Date

1993-12-31

Page Start

163

Page End

168

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 2_Pages 163-168.pdf

PDF . 276.9kB

Link

https://bpsa.journals.ekb.eg/article_70203.html

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https://bpsa.journals.ekb.eg/service?article_code=70203

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

A THIRD DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR THE IN VITRO DETERMINATION OF AMINOGLUTETHIMIDE AND ITS N-ACETYL METABOLITE IN HUMAN PLASMA

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Article

Created At

22 Jan 2023