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70042

SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL THIOLS USING 2,6-DICHLOROQUINONE-4-CHLORIMIDE

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Last updated: 25 Dec 2024

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Abstract

The reaction of thiols with 2,6-dichloroquinone-4-chlorimide (DQC) at pH 7-8 was applied to the quantitative determination of 9 thiol compounds related to different classes (aliphatic, aromatic and heterocyclic). The aliphatic thiols yielded a yellow color (lmax 435 nm) aromatic thiols yielded an orange color (lmax 498-503 nm), sulphathiourea, 2-thiobarbituric acid and thiacetazone yielded violet colors (lmax 540-550 nm). Job's plots indicate a 1:1 ratio of thiol to reagent. Beer-lambert's law is adhered to over the following ranges 2-4 mg ml-1 (for 2-thiobarbituric acid), 3-6 mg ml-1 (for thiosalicylic acid), 4-18mg ml-1 (for thiomersal), 2-14 mg ml-1 (for thiacetazone) 10-70 mg ml-1 (for captopril), 5-25mg ml-1 (for dimercaprol), 10-40 mg ml-1 (for thioglycerol) and 5-30 mg ml-1 (for tiopronin). Common tablet excipient as well as additives in parenteral solutions were found not to interfere. The results of analysis of pure drugs and their dosage forms by the proposed method are ingood agreement with those obtained by official and reported methods.

DOI

10.21608/bfsa.1993.70042

Authors

First Name

M.

Last Name

El-Kommos

MiddleName

E.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

H.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

O.

Last Name

Abdelmageed

MiddleName

H.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

N.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

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Volume

16

Article Issue

2

Related Issue

10642

Issue Date

1993-12-01

Receive Date

1993-03-27

Publish Date

1993-12-31

Page Start

131

Page End

139

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 2_Pages 131-139.pdf

PDF . 454.4kB

Link

https://bpsa.journals.ekb.eg/article_70042.html

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https://bpsa.journals.ekb.eg/service?article_code=70042

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL THIOLS USING 2,6-DICHLOROQUINONE-4-CHLORIMIDE

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Article

Created At

22 Jan 2023