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70041

SPECTROPHOTOMETRIC DETERMINATION OF PIPERAZINE USING 3,5-DIBROMO-2-METHYL-p-BENZOQUINONE

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Last updated: 25 Dec 2024

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Abstract

A spectrophotometric method is developed for the quantitative determination of piperazine either in bulk drug or in pharmaceutical dosage forms. The method is based on the formation of vinylamine of this drug by interaction with acetaldehyde. The resulting enamine interacts with 3,5-dibromo, 2-methyl-p-benzoquinone (DEMQ) forming an intense blue colored aminovinylquinone which can be estimated spectrophotometrically at lmax642 nm. DEMQ is prepared according to a modified oxidation procedure by treatment of 2,4,6 tribromo-3-methylphenol with chromic oxide in a mixture of acetic acid and acetonitrile  (9:1). Beer-Lambert's Law was adhered to over the range of 2-8, 2-9, and 2-10 mg.ml-1 for piperazine hydrate, tartrate, citrate and phosphate respectively. The optimum reaction conditions and the effect of all variables have been studied. The proposed method is simple, rapid, sensitive, accurate, precise and has been applied successfully for the analysis of some pharmaceutical formulations of piperazine including tablets, effervescent granules and syrup with good recoveries. Results obtained are in good agreement with those obtained by the official methods.

DOI

10.21608/bfsa.1993.70041

Authors

First Name

H.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

P.

Last Name

Khashaba

MiddleName

Y.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

-

First Name

A.

Last Name

Mohamed

MiddleName

I.

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

El-Shorbagi

MiddleName

A.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

16

Article Issue

2

Related Issue

10642

Issue Date

1993-12-01

Receive Date

1993-02-24

Publish Date

1993-12-31

Page Start

125

Page End

130

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 2_Pages 125-130.pdf

PDF . 315.0kB

Link

https://bpsa.journals.ekb.eg/article_70041.html

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https://bpsa.journals.ekb.eg/service?article_code=70041

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC DETERMINATION OF PIPERAZINE USING 3,5-DIBROMO-2-METHYL-p-BENZOQUINONE

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Article

Created At

22 Jan 2023