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70040

MICROENCAPSULATION OF THEOPHYLLINE

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Last updated: 25 Dec 2024

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Abstract

Theophylline microcapsules were prepared using the solvent evaporation technique. Each of ethylcellulose (EC) and cellulose acetate butyrate (CAB) was used as a coating material. The adopted technique was simple and efficient. The drug release rate from CAB-coated microcapsules was slower than that from EC-coated ones. Increasing the coating polymer concentration, in the internal phase, from 10 to 20% leads to a decrease in the release rate of the drug. Increasing the CAB/drug ratio from 1:1 to 2:1 leads to a decrease in the release rate. Sealant treatment of EC-coated microcapsules was tried in an attempt to lower the drug release rate thereof. The sealant had a pronounced effect on the release rate. The effect was more enhanced by increasing the sealant concentration. Three sustained release formulations of the microcapsules were prepared and orally administered to asthmatic patients. The drug serum levels revealed a sustained action of the tested formulations.

DOI

10.21608/bfsa.1993.70040

Authors

First Name

A.

Last Name

El-Sayed

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

H.

Last Name

Sayed

MiddleName

Abdel Monem

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Osman

MiddleName

Hamed

Affiliation

Department of Chest, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Fathy

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

16

Article Issue

2

Related Issue

10642

Issue Date

1993-12-01

Receive Date

1993-01-09

Publish Date

1993-12-31

Page Start

113

Page End

123

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 2_Pages 113-123.pdf

PDF . 558.8kB

Link

https://bpsa.journals.ekb.eg/article_70040.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=70040

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

MICROENCAPSULATION OF THEOPHYLLINE

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Article

Created At

22 Jan 2023