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70034

FLUOROMETRIC•DETERMINATION OF ACYCLOVIR IN SPIKED HUMAN PLASMA

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Last updated: 25 Dec 2024

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Abstract

A highly sensitive fluorometric method for determination of acyclovir  is described. The method depends  on the interaction between acyclovir .and 7-hydroxy-4-methylcoumarin where a fluorophore of high fluorogenic activity is formed which has wavelengths of maximum excitation and emission of 342 and 452,respectively. The method is used for determination of acyclovir in human plasma in the range of 5-10 ngm-1 in a rectilinear relationship. The mean percentage recovery was 99.954 S.D. ± 1.450 in case of bulk drug while it was 99.893 S.D.+ 0.711 in case of 6 concentrations of human plasma. The method is recommended for drug monitoring of acyclovir.

DOI

10.21608/bfsa.1993.70034

Authors

First Name

A.

Last Name

Habeeb

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt

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First Name

M.

Last Name

Mabrouk

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt

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Volume

16

Article Issue

1

Related Issue

10639

Issue Date

1993-06-01

Receive Date

1993-02-04

Publish Date

1993-06-30

Page Start

106

Page End

111

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 1_Pages 106-111.pdf

PDF . 697.5kB

Link

https://bpsa.journals.ekb.eg/article_70034.html

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https://bpsa.journals.ekb.eg/service?article_code=70034

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FLUOROMETRIC•DETERMINATION OF ACYCLOVIR IN SPIKED HUMAN PLASMA

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Article

Created At

22 Jan 2023