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70033

PREPARATION AND EVALUATION OF ISONIAZID MICROCAPSULES

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Last updated: 04 Jan 2025

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Abstract

Spherical microcapsules of isoniazid (INH) using ethylcellulose and ethylene vinyl acetate copolymer (EVA) were prepared by a coacervation-phase separation method. The dissolution characteristics of isoniazid from microcapsules with different concentrations of EVA were almost independent of the content of EVA in phosphate buffer PH 7.4 but dissolution properties of microcapsules in 0.lN HcL and water were found to be affected by the content of EVA and there was a negative correlation between the release rate and the content of EVA in the microcapsules. Kinetic data revealed that the release mechanism from microcapsules followed diffusion controlled and zero order Kinetic. The bioavailability of INH microcapsules was studied in rabbits. The mean maximum serum levels (Cmax) and time to maximum serum levels (tmax) were significantly different for INH microcapsules prepared using ethylcellulose only and those prepared with ethylcellulose and EVA copolymer, compared with INH powder. With regard to the area under the curve (AUC) value, there was no significant difference between INH powder and INH microcapsules.

DOI

10.21608/bfsa.1993.70033

Authors

First Name

S.

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

F.

Last Name

Omar

MiddleName

A.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

16

Article Issue

1

Related Issue

10639

Issue Date

1993-06-01

Receive Date

1992-12-17

Publish Date

1993-06-30

Page Start

97

Page End

105

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 1_Pages 97-105.pdf

PDF . 433.3kB

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https://bpsa.journals.ekb.eg/article_70033.html

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https://bpsa.journals.ekb.eg/service?article_code=70033

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

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https://bpsa.journals.ekb.eg/

MainTitle

PREPARATION AND EVALUATION OF ISONIAZID MICROCAPSULES

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Article

Created At

22 Jan 2023