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70032

SYNTHESIS OF NOVEL SUCCINIMIDES: SPIRO-, AND N-MANNICH BASE DERIVATIVES WITH POTENTIAL ANTICONVULSANT ACTIVITY

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Last updated: 04 Jan 2025

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Abstract

Several substituted N-aminomethylsuccinimides (I) and 1'-alkyl, or aralkyl Spiro [indolin-2-one-3,3'-pyrrolidine-2',5 -diones1 (III, XVI) were prepared. The pKa values and the anti-MMS activity of some selected members are reported. Compound XVI showed matching protection mode when compared with ethosuximide.

DOI

10.21608/bfsa.1993.70032

Authors

First Name

Ragab

Last Name

Shafik

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

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City

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Orcid

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First Name

El-Sebai

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Email

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City

-

Orcid

-

First Name

Magdi

Last Name

Abdel-Khalek

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

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-

City

-

Orcid

-

First Name

Mona

Last Name

El-Semary

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

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-

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Volume

16

Article Issue

1

Related Issue

10639

Issue Date

1993-06-01

Receive Date

1992-12-14

Publish Date

1993-06-30

Page Start

88

Page End

96

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 1_Pages 88-96.pdf

PDF . 403.1kB

Link

https://bpsa.journals.ekb.eg/article_70032.html

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https://bpsa.journals.ekb.eg/service?article_code=70032

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9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS OF NOVEL SUCCINIMIDES: SPIRO-, AND N-MANNICH BASE DERIVATIVES WITH POTENTIAL ANTICONVULSANT ACTIVITY

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Article

Created At

22 Jan 2023