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70031

MICROENCAPSULATION OF NITROFURANTOIN BY COACERVATION USING CERTAIN POLYMERIC MATERIALS

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Last updated: 04 Jan 2025

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Abstract

Microencapsulation of nitrofurantoin was carried out in order to prepare sustained release formulations with less side effects. Three coacervation techniques, using three different coating materials, were adopted  for this purpose as follows: non - solvent addition using Eudragit RS 100 (ERS), temperature change using ethylcellulose (EC) and salt addition using sodium alginate (SA). The physical properties as well as the dissolution characteristics were investigated. Microencapsulation of nitrofurantoin (NF) gave rise to sustaining its release at pH 1.12. NF-SA and NF-EC microcapsules showed more retarded release than NF-ERS microcapsules. Increasing the proportion of ERS in its microcapsules resulted in a marked sustaining of NF release whereas, no significant effect was obtained upon increasing the proportion of EC in NF-EC microcapsules. NF microcapsules showed fast release at pH 7.8 specially in case of SA. Regarding the release kinetics, first order model proved to be the most operative mechanism explaining the release of NF from NF-ERS microcapsules. On the other hand, Baker and Lonsdale equation was found to be the most suitable model for explaining the release of NF from EC or SA microcapsules.

DOI

10.21608/bfsa.1993.70031

Authors

First Name

A.

Last Name

Aly

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut Egypt

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City

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Orcid

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First Name

S.

Last Name

Saleh

MiddleName

I.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Ahmed

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Abdel-Rahaman

MiddleName

I.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut Egypt

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City

-

Orcid

-

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut Egypt

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-

City

-

Orcid

-

Volume

16

Article Issue

1

Related Issue

10639

Issue Date

1993-06-01

Receive Date

1992-12-13

Publish Date

1993-06-30

Page Start

73

Page End

87

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 1_Pages 73-87.pdf

PDF . 728.8kB

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https://bpsa.journals.ekb.eg/article_70031.html

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https://bpsa.journals.ekb.eg/service?article_code=70031

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

MICROENCAPSULATION OF NITROFURANTOIN BY COACERVATION USING CERTAIN POLYMERIC MATERIALS

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Article

Created At

22 Jan 2023