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70029

PHARMACOKINETIC STUDY OF NORETHINDRONE COPRECIPITATE

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Last updated: 04 Jan 2025

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Abstract

Pharmacokinetic parameters of norethindrone (NE) were studied in 12 adult female guinea pigs following either oral or rectal administration of a single dose of 2.5 mg. The animals were divided into three groups (4 animals each) and each group was given the single dose either in capsule, tablet or suppository form. NE in blood plasma was determined by HPLC at various time intervals (0.5, 1, 2, 4, 6, 8, 12 hour). The results indicate that NE was readily absorbed by, both routes but the maximum plasma concentration (Cmax) and the area under the plasma concentration time curve AUC of NE were significantly high by the rectal route. No significant differences in the plasma half-life (t1/2), absorption (Ka) and elimination (Ke) rate constants and the time to maximum plasma concentration (tmax) were observed between the oral and rectal administrations. These findings suggest that the rectal route offers the possibility of reducing the effective dose of NE, which is widely used for contraception and hormone replacement therapy.

DOI

10.21608/bfsa.1993.70029

Authors

First Name

S.

Last Name

Abou-El-Ela

MiddleName

H.

Affiliation

Department of Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt

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First Name

S.

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

16

Article Issue

1

Related Issue

10639

Issue Date

1993-06-01

Receive Date

1992-12-01

Publish Date

1993-06-30

Page Start

56

Page End

62

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 1_Pages 56-62.pdf

PDF . 384.0kB

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https://bpsa.journals.ekb.eg/article_70029.html

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https://bpsa.journals.ekb.eg/service?article_code=70029

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

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https://bpsa.journals.ekb.eg/

MainTitle

PHARMACOKINETIC STUDY OF NORETHINDRONE COPRECIPITATE

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Article

Created At

22 Jan 2023