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THE MODE OF INCLUSION COMPLEXATION OF BROMAZEPAM WITH DIMETHYL -CYCLODEXTRIN

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Last updated: 04 Jan 2025

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Abstract

Inclusion complex formation of bromazepam with heptakis- (2 ,6-di-O-methyl)-b-cyclodextrin (DM-b-CD) in aqueous solution was confirmed by the solubility  method. AL-type phase solubility diagram was obtained with 50 folds increase in the solubility of bromazepam. Crystalline inclusion complexes of bromazepam with DM-b-CD in 1 : 1 and 1 : 2 molar ratios were obtained by the co-precipitation method as indicated by the X-ray diffraction analysis. Infrared (IR) spectra of the  inclusion complex ,of bromazepam and DM-b-CD was different depending on the molar ratio, whether it is 1: 1 or 1 : 2. In the same time, the differential scanning calorimetry (DSC) analysis showed different thermal behaviour depending on the molar ratio of the inclusion complex. These results revealed that the mode of molecular interaction of 1 : 1 inclusion complex of bromazepam with DM-b-CD was different from that of 1 : 2.

DOI

10.21608/bfsa.1993.70028

Authors

First Name

S.

Last Name

Saleh

MiddleName

I.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Aly

Last Name

Abdel-Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

Y.

Last Name

Nakai

MiddleName

-

Affiliation

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan

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-

City

-

Orcid

-

First Name

M.

Last Name

Ahmed

MiddleName

O.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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-

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Volume

16

Article Issue

1

Related Issue

10639

Issue Date

1993-06-01

Receive Date

1992-11-04

Publish Date

1993-06-30

Page Start

47

Page End

55

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 1_Pages 47-55.pdf

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https://bpsa.journals.ekb.eg/article_70028.html

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https://bpsa.journals.ekb.eg/service?article_code=70028

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE MODE OF INCLUSION COMPLEXATION OF BROMAZEPAM WITH DIMETHYL -CYCLODEXTRIN

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Article

Created At

22 Jan 2023