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70027

IN VITRO RELEASE OF DIAZEPAM FROM DIFFERENT SUPPOSITORY FORMULATIONS

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Last updated: 04 Jan 2025

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Abstract

The effect of suppository vehicles, drug concentrations, liquid additives and some nonionic surfactants on the in vitro release of diazepam from different suppository formulation were investigated. The obtained data revealed that the drug release is significantly higher from suppository prepared using PEG than the other formulations. The drug release from oleaginous base was related inversely to its partition coefficient and the melting range of the tested oleaginous bases. The incorporation of 'some liquid additives (10%) was found to improve the release pattern of the drug from a PEG base. The degree) of improvement is correlated well to the solubility of the drug .in the utilized additives. The data, also, reveal that the release rate is directly proportional to the drug concentration. The incorporation of nonionic surfactants into Witepsol H15 in a 5% concentration was found to increase the release rate of diazepam. The enhancing effect was found to be dependent on the chemical structure of the surfactants. The release rate of medicament from different solid nonionic surfactants, as suppository bases, was also studied. The magnitude of drug release was markedly reduced as compared with PEG bases.

DOI

10.21608/bfsa.1993.70027

Authors

First Name

Sayed

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

sayed.hussien@pharm.aun.edu.eg

City

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Orcid

-

First Name

Sohair

Last Name

El-Shanawany

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

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Volume

16

Article Issue

1

Related Issue

10639

Issue Date

1993-06-01

Receive Date

1992-09-08

Publish Date

1993-06-30

Page Start

36

Page End

46

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 16_Issue 1_Pages 36-46.pdf

PDF . 555.0kB

Link

https://bpsa.journals.ekb.eg/article_70027.html

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https://bpsa.journals.ekb.eg/service?article_code=70027

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Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IN VITRO RELEASE OF DIAZEPAM FROM DIFFERENT SUPPOSITORY FORMULATIONS

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Article

Created At

22 Jan 2023